Given that AKT/GSK3β-mediated activation of CRMP2 is critical for the axonal regeneration and cognitive function improvement after brain injuries35, the protective effects of XSECC on the cognitive function of rats after CCH may involve the regulation of the AKT/GSK-3β/CRMP2 signal pathway. This evidence concerns the gene DPYSL2 and columnar cell hyperplasia of the breast.