GSK3B and columnar cell hyperplasia of the breast: Furthermore, XSECC treatment markedly attenuated CCH-induced increase in the level of phospho-CRMP2, but increased the expression of phosphorylated AKT and GSK-3β, indicating that XSECC had ability to activate AKT signaling pathway, which might, at least partially, contribute to the effect of promoting neurite outgrowth of XSECC following CCH.