EPHA2 and neoplasm: Importantly, thanks to both the active (YSA–EphA2 interaction) and passive (the enhanced permeability and retention (EPR) effect of nanomaterials)48 tumour-targeting capabilities, the RClosed-YSA NPs can be largely enriched in tumour tissue with maximum tumour uptake of ~7.3% ID g−1 occurring at 4 h post injection.