Among IDH1 and IDH2 mutations, we found preferential selection for IDH1 R132H (glioma low grade, AML and glioblastoma), IDH1 R132C (glioma low grade, AML, liver cancer and melanoma), IDH1 R132G and IDH1 R132S (glioma low grade) above common IDH2 mutations, as well as preferential selection for IDH2 R172K above IDH1 R132C in glioma low grade (Supplementary Fig. 20). This evidence concerns the gene IDH1 and melanoma.