Moreover, compared to the USP49-wild-type mice, the USP49-knockout mice displayed a notable increase in the number of macroscopically visible tumors (Fig. 5e, f) as well as larger and more advanced tumors and an increased incidence of high-grade intraepithelial neoplasia and carcinoma in situ (Fig. 5g). The gene discussed is USP49; the disease is intraepithelial neoplasia.