TGFB1 and neoplasm: Remarkably, TGF-β-mediated increase in tumor-sphere formation was reverted in vitro, in independent PANC-1 KO clones for miR-125b, generated by CRISPR-Cas9 (Fig. 4a, b and Supplementary Fig. 7b, d), but was only partially reduced in clones KO for miR-100 (Fig. 4a, b and Supplementary Fig. 7a, c).