In addition, 2-tRFs (mainly from tRNAGlu, tRNAAsp, tRNAGly, and tRNATyr) can competitively bind to YBX-1 (also referred as YB-1) and block its interaction with oncogenic mRNAs, thereby reducing the stability of these mRNAs and eventually inhibiting metastasis of human breast cancer cells [25]. This evidence concerns the gene YBX1 and breast carcinoma.