There are no previous data on CREB1 in CD, but it has been related to other diseases like human colorectal cancer, where CREB1 acts as a TF for tumor driver RRM2, or glioblastoma, where CREB1 acts as a mediator of the induction of TGFβ2 [35,36]. Here, TGFB2 is linked to colorectal cancer.