Similarly, the pro-angiogenic cytokines such as CXCL1 [chemokine (C-X-C motif) ligand 1], CXCL3, and CXCL6, [chemokine (C-X-C motif) ligand 6], which are typically expressed in highly aggressive cancer, were found to be down-regulated in LNCaP-MST cells. This evidence concerns the gene CXCL1 and cancer.