MUC1 and neoplasm: To ensure that our CAR.MUC1 T cells persist and remain functional at the tumor site, we developed an inverted chimeric cytokine receptor “4/7ICR” (Fig. 1d) containing the cytokine-binding portion of the IL4 receptor linked with the signaling endodomain of IL7 receptor, which we co-expressed with 1G CAR [Fig. 1e -mean 71.5 ± 3% double positive (1G.4/7ICR) T cells].