Bladder cancer cells transfected with anti-sense to hyaluronic synthases1 (HAS1) showed downregulation in expression of CD44v3, CD44v6, and CD44s both at mRNA and the protein levels indicating that HAS1 regulates the growth of bladder cancer cells by modulating HA synthesis and HA receptor levels [32]. This evidence concerns the gene HAS1 and urinary bladder carcinoma.