TP53 and B-cell chronic lymphocytic leukemia: In December 2016, venetoclax monotherapy received the approval of the European Medicines Agency for the treatment of CLL in the presence of 17p deletion or TP53 mutation in adult patients who are unsuitable for or have failed a B-cell receptor pathway inhibitor (BCRi); and for CLL in the absence of 17p deletion or TP53 mutation in adult patients who have failed both chemoimmunotherapy and a BCRi [57].