Furthermore, CLDN11 mRNA expression levels were restored upon DNA methylation inhibitor, 5’Aza, treatment in the three NPC cells C666.1, HK1, and TW02, but not in TW06 (Fig. 2d), suggesting that transcriptional repression of CLDN11 by DNA methylation is occurred in NPC cells. Here, CLDN11 is linked to nasopharyngeal carcinoma.