MGMT and glioblastoma: Otherwise, it has been reported that low MGMT nuclear expression, evaluated by immunohistochemistry, is associated with better outcomes only in patients with BRAF mutations treated with a cisplatin, vinblastine and temozolomide regimen as the first-line therapy [23], and in glioblastoma, MGMT methylation greater than 35% has been described as an independent prognostic factor associated with better outcomes [24, 25].