The top 10 putative target proteins associated with AD, in turn, were nitric oxide synthase (NOS3), neprilysin (NEP), beta-secretase 1 (BACE1), estrogen receptor (ESR1), amine oxidase B (MAOB), prothrombin (F2), serum albumin (ALB), transthyretin (TTR), matrix metalloproteinase-3 (MMP3), and interleukin-2 (IL2). This evidence concerns the gene MMP3 and Alzheimer disease.