Src is also essential for the wound healing and fibrotic events where p-GSK3β (Tyr216) played an important role in fibrotic events mean that Src kinase may modulate the GSK3β activity [86], which might be in agreement with our study that KRT19 mediated cancer stem cell reprogramming might be through the regulation of Src/GSK3β phosphorylation at Tyr216 in breast cancer. This evidence concerns the gene KRT19 and breast carcinoma.