In fact, the levels of EGF, MMP-9 and phosphorylated AKT are extremely low or undetectable in the normal uterine cervix, becoming appreciable in low-grade CIN and further increasing during its evolution to high-grade CIN and CC [103,107,113,196,197,198]. The gene discussed is AKT1; the disease is cervical squamous intraepithelial neoplasia.