Conversely, a renal protective role of Nrf2 is supported by the finding that dietary Nrf2 activators such as sulforaphane or cinnamic aldehyde limited albuminuria and protected against renal oxidative damage in rats with streptozotocin-induced diabetes, suggesting that Nrf2 may be a potent therapeutic target in kidney diseases [20]. Here, NFE2L2 is linked to diabetes mellitus.