Since leiomyomas are considered estrogen-dependent tumors, and leiomyoma tissue is more sensitive to estradiol (has more estrogen receptors in comparison to normal myometrium), authors suggested that the loss of the TC network might lead to myocytes taking up the hormonal sensor function, which can determine an uncontrollable proliferation of myocytes [38]. This evidence concerns the gene ESR1 and leiomyoma.