NKX2-5 and acute lymphoblastic leukemia: Several oncogenic NKL homeobox genes in T-ALL are aberrantly activated via chromosomal translocations like t(10;14)(q24;q11) juxtaposing a TCR-enhancer with TLX1 or t(5;14)(q35;q32) a BCL11B-enhancer with TLX3 or NKX2-5 [7,19,20].