These up-regulated genes predominantly belonged to either glycolysis or the pentose phosphate pathway (ALDOA, ENO1, ENO2, HK2, PDK3, PDP2, PFKL and PGK1, PRPS1, PRPS2 and RPE), which supports a direct role for KSHV-infection in elevation of glycolysis. This evidence concerns the gene PFKL and Kaposi's sarcoma.