In the half of polyps in CRS patients EGFR expression was absent but not in the other half.[34] Interestingly, our result revealed that EGFR expression in the polyp epithelium was decreased, which is supported by the previous report that EGFR expression and phosphorylation in human bronchial epithelial cells are downregulated by prolonged exposure to human dust mites mimicking chronic allergic inflammation.[35]. Here, EGFR is linked to congenital rubella syndrome.