Similar to CDO1, a cut-off value of 0.01 (sensitivity 52%, specificity 95%, AUC = 0.73) was obtained using ROC curve analysis to distinguish between NAM and low-grade adenoma with SEPT9. In addition, a cut-off value of 0.34 (sensitivity 80%, specificity 67%, AUC = 0.73) was obtained to distinguish between low-grade adenoma and high-grade adenoma (S1 Fig). The gene discussed is CDO1; the disease is adenoma.