THBS1 and infection: The TSP‐1 domain‐containing protein could also be a promising immunogenic candidate, given that S. mansoni TSP proteins have shown great potential in preclinical and Phase I clinical trials.44, 45 It is interesting to note that infection alone does not generate antibody responses against EVs or their contents, at least as assessed by Western blotting; however, this may reflect the sensitivity of the assay.