TENM4 and depressive symptom measurement: These include genome-wide association with (1) schizophrenia (such as the major histocompatibility complex, MHC, region at 6p22-p21 [37]; (2) depression [38]; (3) bipolar disorder [39], including the variants within ANK3 [40], NCAN [41], CACNA1C and ODZ4 [42] and (4) specific chromosomal regions: 2q, 5, 7q, 15q, 16p [43, 44] and risk genes [45, 46] for autism.