Upregulated genes were enriched in TNF signaling pathway, osteoclast differentiation, chemokine signaling pathway, cytokine-cytokine receptor interaction, rheumatoid arthritis, while the only three KEGG pathways found in the downregulated genes were biosynthesis of amino acids, biosynthesis of antibiotics and glycine, serine and threonine metabolism. Here, TNF is linked to rheumatoid arthritis.