GAS5, an important tumor suppressor lncRNA, is a promising diagnostic and prognostic cancer biomarker.14 Two recent studies indicated that GAS5 is downregulated in human ESCC tissues and inhibits the growth of ESCC cells.27, 28 In this study, we found that GAS5 was upregulated in ESCC tissues in public data sets and acted as a tumor suppressor gene. Here, GAS5 is linked to neoplasm.