IFNA1 and esophageal cancer: IFN mainly functions through the JAK (Janus activated kinase)‐STAT signaling pathway and plays an antitumor role.19 IFNs also play an antitumor role in esophageal cancer.20, 21 We next used another online database, Jaspar, to confirm the interaction between the STAT family and the GAS5 promoter.