The lncRNA GAS5 (growth arrest‐specific transcript 5) was identified as a pivotal tumor suppressor in several human cancers, including breast cancer, prostate cancer, lung cancer, and colorectal cancer.11 GAS5 can inhibit the proliferation and promote the apoptosis of cancer cells, mainly through repressing steroid receptor‐induced transcriptional activation, acting as an miRNA sponge and directly interacting with functional proteins.12 However, the function and mechanisms of GAS5 in ESCC remain largely unstudied. This evidence concerns the gene GAS5 and neoplasm.