To address this gap, we selected 13 potentially functional and tagging SNPs in BMP2 (rs1979855, rs170986, rs1980499, rs235768, rs3178250), BMP4 (rs4898820, rs762642, rs17563), Smad4 (rs12456284), and Hamp (rs1882694, rs10402233, rs10421768, rs12971321), hypothesizing that these SNPs in hepcidin regulatory BMP/Smad4/Hamp would be correlated with outcomes among patients with NSCLC after definitive radiotherapy. The gene discussed is SMAD4; the disease is non-small cell lung carcinoma.