ZEB1 binding to RUNX2 and Smad motifs in breast cancer cells appears functionally likely, as RUNX2 regulates mesenchymal progenitor to osteoblast differentiation, and mutations in RUNX2 perturb the RUNX2‐Smad association, linking to syndromes of craniofacial dysplasia (Zhang et al., 2000). This evidence concerns the gene ZEB1 and breast carcinoma.