Interestingly, we noticed that delta miRNA-5195 expression positively correlates with delta DAS28 (p = 0.039, r = 0.67) (Fig. 4a), whereas changes in CRP level did not correlate with delta DAS28 in RA patients (p = 0.38, r = − 0.30) (Fig. 4b). This evidence concerns the gene CRP and rheumatoid arthritis.