Based on prediction algorithms obtained from miRDB, Target Scan Human and miRanda databases, miRNA-5196 has been described as a negative regulator of Fra2 (AP-1 family transcription factor) and MMP-15, IL-1 receptor type I. These molecules play an important role in inflammation and progression of rheumatic diseases (Araki and Mimura 2017; Dey et al. 2016; Magyari et al. 2014). The gene discussed is MMP15; the disease is rheumatic disorder.