In Fig. 6a, b, it can be seen that delta miRNA-5196 was much more specific in predicting anti-TNF-α response (area under curve (AUC) = 0.87, CI = 0.63–1.11, p = 0.055 and AUC = 0.90, CI = 0.67–1.21, p = 0.050, respectively, in RA and AS patients) than delta CRP level (AUC = 0.83, CI = 0.56–1.10, p = 0.088 and AUC = 0.85, CI = 0.56–1.13, p = 0.086, respectively, in RA and AS patients). The gene discussed is TNF; the disease is rheumatoid arthritis.