On the contrary, and without interactions with other overexpressed proteins, PTPN12 (tyrosine-protein phosphatase nonreceptor type 12) is a tumor suppressor protein and has been associated with overall survival in esophageal squamous cell carcinoma patients and non-small-cell lung cancer [30, 31]. The gene discussed is PTPN12; the disease is esophageal squamous cell carcinoma.