Our results are consistent with early reports that treatment with recombinant adiponectin markedly alleviated hepatomegaly and fatty liver, as well as significantly attenuated elevated levels of serum ALT in nonalcoholic obese ob/ob mice [31], which spontaneously develop hyperinsulinemia, insulin resistance, and steatosis due to an inherited leptin deficiency [32]. This evidence concerns the gene ADIPOQ and Insulin resistance.