Similarly, Rainer et al., using a mouse model of selective TGF-β receptor 1 or 2 knockout, demonstrated that the inhibitory effects of TGF-β signaling on cardiomyocytes could significantly suppress neutrophil aggregation in the heart, restrain the inflammatory reaction, prevent cardiac rupture after MI, and improve remodeling [126]. Here, TGFB1 is linked to myocardial infarction.