It was observed that binding of PGF to VEGFR1 stimulated phosphorylation of VEGFR1, induced activation of ERK1/2, PI3K, p38 and c‐Jun N‐terminal kinase and mediated their effects on the pathological conditions of vascular endothelial cell growth, inflammation and angiogenesis in several cancer cells 29, 30, 31. Here, FLT1 is linked to cancer.