Obesity/HFD‐induced hypothalamic inflammation is characterized by accumulation of glial cells (astrocytes and/or microglia) and their activation 11, 24, 25, 26, 27, leading to metabolic dysregulation including leptin/insulin resistance and thermogenic impairment 28, 29, 30. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.