For example, several TNF receptor superfamily (TNFRSF)/ligands such as CD40/CD40L and TWEAK/FN14 also participate in glial cell‐mediated central/neuronal inflammatory diseases such as Alzheimer's disease and MS 31, 32 and are considered as a potential therapeutic target. The gene discussed is TNFSF12; the disease is early-onset autosomal dominant Alzheimer disease.