BIRC5 and non-small cell lung carcinoma: Mann–Whitney U‐test demonstrated that plasma anti‐BIRC5a IgG levels were significantly higher in patients with NSCLC than control subjects (Z = −4.06, P < 0.001), and male patients mainly contributed to the increased anti‐BIRC5 IgG levels in NSCLC (Z = −4.16, P < 0.001); however, neither anti‐BIRC5b IgG nor anti‐MYC IgG levels showed a significant change in patients with NSCLC compared with controls subjects (Table 4).