IL1RL2 and psoriasis: Thus, damage to keratinocytes resulting in the liberation of IL‐36 cytokines, either as a result of microbial infection or as a consequence of tissue trauma, may play an important initiating role in psoriasis, especially in individuals lacking endogenous buffers of IL‐36 activity, such as deficiency in the IL‐36R antagonist 16, 17, 18, 19, 20.