DNMT1 and cancer: We included the 7 direct targets reported in PrCa (MMP2, DEDD2, NDRG2, AR, LMNB1, PARVA, SLC8A1) and 16 direct targets empirically validated in other cancers compiled in TarBase (RUNX3, TP53INP1, PPARG, CSF1, UVRAG, ZEB1, DICER1, STAT3, PDGFRA, ZBTB4, PTEN, SMAD4, ITGB1, CCNA2, PPARGC1A, FMR1 for miR-130b and TP63 and DNMT1 for miR-301b) [61] (Table 2).