VEGFA and macular retinal edema: The VEGF Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (COPERNICUS) and the General Assessment Limiting Infiltration of Exudate in Central Retinal Vein Occlusion with VEGF Trap-Eye (GALILEO) studies both evaluated the use of aflibercept in the treatment of macular edema from CRVO.