Lin et al. [8] used mice with varying immune repertoires, including Rag1−/−, NSG, PD-L1−/− and PD-1−/− mice, for studying PD-L1 and PD-1 signaling blockade in MC38, ID8 (ovarian cancer), B16-F10 (melanoma), and LLC (lung cancer) tumor models. This evidence concerns the gene CD274 and melanoma.