As oxidative stress is closely linked to the inflammation in T2DM, the anti-inflammatory effects of CUR have also been observed in the liver of insulin-resistant animals, where dietary CUR reduced the activity of NF-κB and several inflammatory markers such as SOCS3, TNFα, MCP1, and chemokine (C-C motif) ligand-2 (CCR-2) [22]. The gene discussed is TNF; the disease is type 2 diabetes mellitus.