The beneficial effects of CUR have also been observed in other diabetic animal models such as KK-Ay mice, in which CUR reduced hyperglycemia through PPARγ activation [42], and C57BL/KsJ-db/db mice, in which CUR reduced insulin resistance and hyperglycemia as a result of the increased blood insulin concentration that subsequently leads to enhanced glycolysis and impaired gluconeogenesis in the liver and augmented LPL activity in skeletal muscle [17]. Here, INS is linked to Insulin resistance.