MAP3K5 and osteosarcoma: The relationship between CUR-mediated ROS generation and apoptosis was further confirmed in gastric cancer cells (where ROS induced the apoptosis signal-regulating kinase 1 (ASK1)/MAPK kinase (MKK) 4/c-Jun N-terminal kinase (JNK) signaling pathway) [61] and osteosarcoma cells (where ROS induced the mitochondrial cytochrome c/caspase 3 apoptotic pathway) [62].