In fact, curcuminoids supplementation (300 mg/day for 3 months) in overweigh/obese T2DM patients reduced the plasma levels of fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), FFAs, TGs, C-reactive protein (CRP), TNFα, IL-6, and adipocyte fatty acid-binding protein (A-FABP, also termed FABP4). Here, TNF is linked to type 2 diabetes mellitus.