As rosiglitazone is the antihyperglycemic drug that acts through the activation of peroxisome proliferator-activated receptor γ (PPARγ), that is, a number of the nuclear hormone receptor superfamily that regulates the transcription of several genes involved in adipocyte differentiation, glucose and lipid metabolism, and inflammation [40], its antidiabetic efficiency was compared to that of CUR in rodents with diet-induced insulin resistance [41]. Here, PPARG is linked to Insulin resistance.