In breast cancer cells, CUR downregulated MMP9 by blocking the PKCα/MAPK/NF-κB/AP1 pathway (in the MCF7 cell line) or the TGFβ/Smad and TGFβ/ERK signaling pathways (in the MDA-MB-231 cell line) [68, 69]. The gene discussed is TGFB1; the disease is breast carcinoma.