In addition to zinc deficiency, a high level of Zn2+ can inhibit glycolysis via its inhibitory effects on glyceraldehyde-3-phosphate dehydrogenase (GAPDH) [79], phosphofructokinase [80], and muscle pyruvate kinase [81]; however, these effects can be reversed by a high level of histidine. This evidence concerns the gene GAPDH and Zinc deficiency.