Given that TLR4 enhances TGF-β1 signaling in hepatic fibrosis [9] and Andro downregulates the expression of TGF-β1, we suppose that the protection of Andro against liver fibrosis has a direct correlation with shutting down the TLR4 and TGF-β1 signaling pathways. This evidence concerns the gene TLR4 and Hepatic fibrosis.