The expression of 9/18 ATG genes, operative in different phases of autophagosome biosynthesis, was significantly inhibited in AML as compared to their expression in mature, healthy granulocytes: ULK1, FIP200, BECN1, ATG14, ATG5, ATG7, ATG3, ATG4B, and ATG4D. The gene discussed is ATG4D; the disease is acute myeloid leukemia.