Considering that DAB2IP plays a critical role in regulating the activation of ERK1/2 pathway in colorectal cancer [13, 31] and activation of ERK1/2 signaling pathway contributes to tumor cell growth and metastasis [21–23], we asked whether DAB2IP modulates the growth and metastasis of gastric cancer cells via regulating ERK1/2 signaling pathway. This evidence concerns the gene MAPK3 and gastric cancer.