Given the evidence that ERK1/2 signaling pathway was identified as one of the most significantly altered pathway when DAB2IP was knockdown in cancers [13] and the ERK1/2 signaling pathway plays a central role in the process of tumor cell growth and metastasis [21–23], we sought to test whether ERK1/2 pathway is implicated in the DAB2IP-mediated gastric cancer cell growth and metastasis. The gene discussed is DAB2IP; the disease is gastric cancer.