DAB2IP and neoplasm: In cancers, downregulation of DAB2IP has been demonstrated to be involved in tumor cell proliferation, apoptosis, metastasis, and epithelial-mesenchymal transition (EMT) through several signaling pathways, including Ras-ERK, PI3K-Akt, ASK1-JNK, and NF-κB [7, 11–13].