FAS and diabetes mellitus: Thus, at the molecular level, we examined the expressions of PPARs and their downstream metabolic genes in mouse livers by reverse transcription-polymerase chain reaction and found that PPARγ and its target genes, including ACC1, ACC2, FAS, SCD1, and SREBP1-C, were significantly higher in diabetes + KD mice while attenuated in the combination of KD and exercise (Figures 6(a)–6(f)).