AVP and Hypocalcemia: Regarding the variable degree of ADH clinical phenotypes as seen in the affected family members, it is evident that I-2 and II-3 had symptoms of severe hypocalcemia, whereas II-2 had a form of asymptomatic mild hypocalcemia, which could indicate that the low S-calcium(total) level together with the very low ionized calcium level might cause the severe clinical symptoms, as I-2 and II-3 had 1.9 and 2.1 mmol/L S-calcium(total), respectively compared to 2.2 mmol/L S-calcium(total), which is the borderline of the reference interval.