Insulin resistance is associated with higher P-Tau 181 and Total Tau in the CSF of asymptomatic late-middle-aged adults with risk factors for AD (APOEε4 carriers) and the association is negative for the APOEε4 non-carriers; whereas there is no effect on CSF Aβ42 levels (Starks et al., 2015). The gene discussed is MAPT; the disease is Insulin resistance.