Insulin resistance increases AD risk by at least two-fold (Sims-Robinson et al., 2010), and this deleterious effect can be due to the disruption of the function of the brain vasculature (Biessels and Reijmer, 2014; Frosch et al., 2017), and/or direct effects on Aβ aggregation or tau phosphorylation. The gene discussed is MAPT; the disease is Alzheimer disease.