In addition, in vivo and in vitro experiments show that Aβ induces serine phosphorylation of insulin receptor substrate 1 (IRS-1) instead of tyrosine phosphorylation (Bomfim et al., 2012); this switch has been described as a major mechanism that triggers peripheral insulin resistance (Hirosumi et al., 2002). This evidence concerns the gene IRS1 and Insulin resistance.