ERBB2 and breast neoplasm: In addition, enhanced angiogenesis and abridged apoptosis in breast tumors have been shown to correlate with ERBB2 gene amplification (Owens et al., 2004[27]; Yaziji et al., 2004[41]; Kim et al., 2008[18]; Birnbaum et al., 2009[3]; Ross et al., 2009[30]; Meinhardt et al., 2015[26]; Chamizo et al., 2016[5]).