We found that daidzein and ERB-041 decreased p-PI3K85, p-AKT, p-GSK3β, and cyclin D1 expression, suggesting PI3K/AKT/GSK3β/cyclin D1 signaling is linked to daidzein and ERB-041 induced G1 cycle arrest in ovarian cancer. The gene discussed is GSK3B; the disease is ovarian cancer.