GSK3B and ovarian cancer: Moreover, genistein, daidzein and ERB-041 also suppressed phosphorylation of Phosphatidylinositol 3 kinase (PI3K)85 and GSK3β, upstream and downstream of AKT respectively [25, 26], suggesting that genistein, daidzein and ERB-041 could modulate PI3K85/AKT/GSK3β signaling in ovarian cancer (Fig. 9).