It has been proposed that upregulation of FGFRs (as seen in patients 4, 9 and 10, as well as to a minor degree in patients 7, 12, 14 and 15, Fig. 5) could be involved in the development of resistance to anti-VEGFR therapies, since both pathways are regulating tumour neoangiogenesis (as reviewed in73). This evidence concerns the gene KDR and neoplasm.