Several proteins involved in the (re-)organization and assembly of the extracellular matrix were significantly overexpressed in all primary tumours compared to normal tissue mucosa (Table S8): Matrix Metallopeptidases, Collagens, Asporin, Fibronectin, Laminin, Lysyl Oxidases, Microfibrillar-Associated Protein, Periostin, Serpin Inhibitors, Osteonectin and Osteopontin. This evidence concerns the gene SPARC and neoplasm.